Cannabinoids reveal separate controls for whisking amplitude and timing in rats



Pietr MD, Knutsen PM, Shore DI, Ahissar E, Vogel Z
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

Whisking is controlled by multiple, possibly functionally segregated, motor sensory-motor loops. While testing for effects of endocannabinoids on whisking, we uncovered the first known functional segregation of channels controlling whisking amplitude and timing. Channels controlling amplitude, but not timing, were modulated by cannabinoid receptor type 1 (CB1R)...

Citation: J Neurophysiol. 2010 Nov;104(5):2532-42. Epub 2010 Sep 15